Palliative Care

Clinical trials for end of life care and symptom control. This includes pain management, breathlessness and loss of appetite.

f you would like to be considered for a clinical trial you will require a referral from your current treating team. Visit the Joining a Clinical Trial page for referral information. 

For more information on clinical trials, get in contact with our cancer clinical trials enquiry coordinator.

Clinical Trials Enquiry Coordinator

Business hours, Mon to Friday between 9am - 2pm
Email Clinical Trials Enquiries
Phone (03) 8559 7456

Open and Recruiting Clinical Trials

A clinical trial to test if the treatment Oxycodone/Naloxone prolonged release is better than Oxycodone prolonged release for managing pain and bowel issues in patients with advanced cancer

Cancer Type

Palliative Care

Status

Open and recruiting

Phase

Four: A phase four clinical trial monitors safety in real world, assessing new products with products that are already available. This is typically the safest type of clinical trial because the treatment has already been studied a lot and might have already been used in many people. Phase four studies look at safety over time. These studies may also look at other aspects of the treatment, cost of the product and patients quality of life.

Brief summary

Oxycodone prolonged release is the most common treatment used in Australia to reduce the severity of moderate to severe pain caused by cancer. The treatment usually lasts for 12 hours and is taken by mouth twice a day (12 hours apart). Naloxone is a type of treatment that can reduce the side effects of Oxycodone. At low doses, the combination of Oxycodone/Naloxone is expected to reduce the constipating effects of Oxycodone, without reducing pain relief. Treatment will be given over a 5 week period and will aim to test which combination has the best results with less side effects.

Who can participate

Patients who:

  • Have a solid cancer that has spread to other parts of the body or a haematological malignancy
  • Have moderate to severe cancer-related pain

Clinical trials can have restrictive criteria of who can and can’t participate, talk to your doctor if you are interested in this clinical trial.

A clinical trial to test if the treatment Melatonin can prevent a condition called delirium in patients with cancer who have been admitted to hospital

Cancer Type

Palliative Care

Status

Open and recruiting

Phase

Three: A phase three clinical trial follows a phase two, in a larger group of patients with specific cancer types. The aim of a phase three is to compare the new treatment to what is available for that cancer type.

Brief summary

This is because you have cancer have been recently admitted in hospital.

The research project is testing a new treatment for delirium, which is a condition that can occur when someone is medically unwell and admitted to hospital. Delirium is particularly common for people with cancer. The new treatment is called melatonin.

The purpose is to investigate whether a medication called melatonin, can prevent a condition called delirium in cancer patients when they are admitted to hospital.

Delirium is a medical condition that can develop when someone is unwell, and is a common problem when people with cancer are admitted to hospital. The treatment Melatonin is approved in Australia to treat specific types of sleep disorders. Melatonin has shown to be effective to reduce delirium frequency / duration. The aim of the clinical trial is to test if the treatment Melatonin is safe and effective in treating delirium for patients with cancer who have been admitted into hospital.

Who can participate

Patients who:

  • Have had treatment for their cancer but it has gotten worse or not responded to treatment given for their cancer

Clinical trials can have restrictive criteria of who can and can’t participate, talk to your doctor if you are interested in this clinical trial.

A clinical trial to test the effect of medicinal cannabis on the quality of life and symptom control in patients with advanced cancer

Cancer type

Palliative care

Status

Opening Soon

Phase

One/two: A phase one / two clinical trial combines a phase one and two. The phase one tests new treatments sometimes for the first time in humans, usually in a small group of patients. The phase two part tests the new treatment in a larger group of patients with selected cancer types.

Brief summary

The aim of palliative care is to provide relief from pain and other distressing symptoms. This study will evaluate whether CGL002 (medicinal cannabis) can improve quality of life, as well as other symptoms (such as nausea, loss of appetite, pain, difficulty sleeping and anxiety) in people with advanced cancer who are undergoing palliative care, and how satisfied people are with the use of this medication

Some research shows that medicinal cannabis can help relieve side effects from cancer or cancer treatment

A clinical trial to determine the effect of medicinal cannabis on the quality of life of patients with advanced cancer. Patients on clinical trial will receive either of the following:

Arm 1: Medicinal cannabis

Arm 2: placebo (a pill/liquid that contains no medicine)

The patient or clinical trial doctor will not know whether the patient is receiving the medicinal cannabis or placebo.

Who can participate

Patients who:

  • Have any type of advanced cancer
  • Are able to swallow medication

Clinical trials can have restrictive criteria of who can and can’t participate, talk to your doctor if you are interested in this clinical trial.