Target discovery and validation

Our researchers strive to link recent advances in genetics, genomics, cell and chemical biology, pharmacology, and medicine for improved drug target discovery through the efforts of our research laboratories and core facilities. Approaches include in vitro and in vivo screening, small molecule high-throughput screening, pre-clinical imaging, and genetically engineered mouse models, among many others


  • Next Generation Sequencing 

  • High density SNP arrays 

  • Expression Profiling 

  • Proteomics 

  • Bioinformatics and Computational Biology

Visit Molecular Genomics Core for more information

Functional genomics 

  • shRNA lentiviral libraries 

  • siRNA high-throughput screening 

  • High content imaging

Visit Victorian Centre Functional Genomics for more information

Tissue banks 

  • biospecimens with cancer tissue from 11,000 patients 

  • Victorian Cancer Biobank collaborations

Visit our Tissue Bank webpage for more information

Genetically engineered mouse models of cancer 

  • Solid tumours 

  • Haematological 

Primary human cancer xenografts 

  • Solid tumours 

  • Haematological 

Drug evaluation 

  • in-vitro testing 

  • in-vivo testing 

  • small molecules 

  • biologics 

Drug discovery 

  • CRC for Cancer Therapeutics 

Pre-clinical imaging 

  • PET (Positron Emission Tomography) 

  • Ultrasound 

  • Tracer development