The program works across multiple tumour streams to uncover markers of risk and to develop precision therapeutics. The program encompasses three main themes: Risk and Prevention (Britt and Campbell labs); Therapy and Resistance (Christie, Clemons, Gorringe, Phillips and Ramsay labs); and Progression and metastasis (Fox, Parker, and Stacker labs).
The constituent laboratories explore these themes using a wide variety of approaches and technologies including whole-genome and single-cell genomics and transcriptomics; in vitro and in vivo tumour models, including patient-derived and animal models; high-content and spatial imaging; and high-throughput functional genomics, small molecule screening and biomarker discovery platforms.