Cancer Evolution and Metastasis Program

The Cancer Evolution and Metastasis Program focuses on understanding the mechanisms of cancer initiation, progression, and metastatic spread

The program works across multiple tumour streams to uncover markers of risk and to develop precision therapeutics. The program encompasses three main themes: Risk and Prevention (Britt and Campbell labs); Therapy and Resistance (Christie, Clemons, Gorringe, Phillips and Ramsay labs); and Progression and metastasis (Fox, Parker, and Stacker labs).

The constituent laboratories explore these themes using a wide variety of approaches and technologies including whole-genome and single-cell genomics and transcriptomics; in vitro and in vivo tumour models, including patient-derived and animal models; high-content and spatial imaging; and high-throughput functional genomics, small molecule screening and biomarker discovery platforms.