Anna Trigos lab

The Anna Trigos lab, also known as the Multi-omic Evolution and Ecosystems lab, focuses on understanding cancer evolution and cancer ecosystems through the analysis of -omics data and the application of computational methods

While cancer treatments have generally focused on targeting individual genes or pathways, cancer cells use a diversity of strategies to become resistant to treatment, such as reprogramming of the transcriptome, epigenome and other -omes, as well as altering the surrounding microenvironment. The Trigos lab focuses on understanding how different -omics layers in tumour cells and the microenvironment adapt and co-evolve as an ecosystem to drive cancer progression, resistance and metastasis. We address these questions using a computational top-down approach to profile patient samples collected from biospecimen collection programs or clinical trials. This insight into cancer enables us to develop novel approaches to identify predictive biomarkers and vulnerabilities that can be targeted with treatment, both of which can be readily translated to the clinic.

Our projects are primarily in prostate cancer and multiple myeloma. We collaborate widely with clinicians, including medical oncologists, nuclear medicine physicians, radiation oncologists and surgeons. Throughout our projects we use a combination of bulk, single-cell and spatial -omics data, including genome sequencing, gene expression, methylation, chromatin accessibility, single-cell RNAseq and multiome, as well as spatial transcriptomics and proteomics platforms (e.g. Visium, OPAL, MIBI, CODEX, Nanostring Digital Spatial Profiling).

Current projects

Lab experts

  • David Kaplan, Postdoctoral researcher
  • Sirui (Cathy) Weng, PhD student
  • James Comben, PhD student
  • Lachlan Cain, Bioinformatician
  • David Le, Honours student
  • Graeme Sissing, Consumer representative
  • Steve Cavill, Consumer representative
  • Geoff Nyssen, Consumer representative

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