The Cox laboratory

In the Cox laboratory, we use zebrafish (Danio rerio) as a model system to study the metabolic regulation of growth during embryonic development, regeneration and cancer

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and among the most fatal cancer types. Although the pathophysiology of HCC has not been fully elucidated, the process clearly arises in the context of chronic liver disease brought on by environmental factors, which conspire with oncogenic pathways to initiate tumourigenesis. One of the emerging hallmarks of cancer is reprogramming of metabolism. The Cox laboratory takes advantage of cutting-edge technologies including multiphoton microscopy, metabolomics, transcriptomics, and chemical genetic screens to elucidate the molecular underpinnings of metabolic reprogramming in cancer.

Current projects

Lab members

Dr Athena Ong, Anthony Karamalakis, Cerys Bladen, Madeline Webb, Mikaela Wong, Tara Tigani, Arina Abramovich

Related links

The University of Melbourne - Andrew Cox lab

Andrew Cox Bio

Andrew Cox Twitter

Andrew PubMed

Google Scholar

Related pages

Discovery of a metabolic pathway that fuels liver regeneration

Discovery that NRF2 activation induces the biogenesis of lysosomes

Discovery that oncogenic YAP stimulates de novo lipogenesis

Cancer Cachexia Clinic and Research Integration Program (CaXI)


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