Professor Henderson is a Professor of Surgery with the The University of Melbourne and surgeon in the Melanoma and Skin Service, Breast Service and Sarcoma Service at Peter Mac. He graduated in medicine from The University of Melbourne and trained as a general surgeon. He completed his training with a Fellowship in Surgical Oncology at the University of Texas MD Anderson Cancer Centre in Houston.
Melanoma makes up a major part of his clinical workload and he is actively involved in clinical and translational research. He maintains an active clinical and translational research interest in melanoma and breast cancer and is supervising several higher degree research candidates. He has a leadership role in education for Peter Mac.