Professor Tony Papenfuss is head of the Bioinformatics and Cancer Genomics Laboratory at the Peter MacCallum Cancer Centre and holds a joint lab head position in the Bioinformatics division at The Walter and Eliza Hall Institute of Medical Research. He is the Lorenzo and Pamela Galli Melanoma Research Fellow. The main focus of his labs research is the analysis of next generation sequence data. Associate Professor Papenfuss' background is in mathematics and his lab consists of mathematicians, statisticians, physicists and computer scientists, who develop novel bioinformatics methods to make sense of cancer genomics data. He has strong interests in melanoma genomics, in cancer evolution and heterogeneity, and in developing methods to detect genomic rearrangements in tumours. Recent research also includes mathematical models of chromosomal shattering and the breakage-fusion-bridge mechanism.