Associate Professor Paul James is a Consultant Clinical Geneticist. He is the director of the Parkville Familial Cancer Centre at the Peter MacCallum Cancer Centre and Royal Melbourne Hospital, and a Clinical Associate Professor in the Department of Medicine, Monash University and the Sir Peter MacCallum Department of Oncology, Melbourne University. He is the group leader for Familial Cancer Research at the Peter MacCallum.
Paul leads a program of clinical research including discovery and translational projects emphasising familial cancer and the genetics of inherited cardiac disorders, with support from the Victorian Cancer Agency, Cancer Australia, Cancer Council NSW, the National Heart Foundation and the NHMRC. He is the principal investigator for a large-scale translational program (known as the ‘Variants in Practice (ViP)’ study) to investigate the familial component of breast and ovarian cancer in Victorian families and implement new models of genetic risk assessment.
Thompson ER, Rowley SM, Li N, McInerny S, Devereux L, Wong-Brown MW, Trainer AH, Mitchell G, Scott RJ, James PA, Campbell IG (2016 May). Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care. J Clin Oncol. 1;34(13):1455-9.
Li H, Feng B, Miron A, Chen X, Beesley J, Bimeh E, Barrowdale D, John EM, Daly MB, Andrulis IL, Buys SS, Kraft P, kConFab investigators, Thorne H, Chenevix-Trench G, Southey MC, Antoniou AC, James PA, Terry MB, Phillips KA, Hopper JL, Mitchell G and Goldgar DE (2017 Jan). Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab." Genet Med;19(1):30-35.
Ballinger ML, Goode DL, Ray-Coquard I, James PA, Mitchell G, Niedermayr E, Puri A, Schiffman JD, Dite GS, Cipponi A, Maki RG, Brohl AS, Myklebost O, Stratford EW, Lorenz S, Ahn S-M, Ahn J-H, Kim JE, Shanley S, Beshay V, Randall RL, Judson I, Seddon B, Campbell IG, Young MA, Sarin R, Blay J-Y, O’Donoghue SI, Thomas DM, for the International Sarcoma Kindred Study† Monogenic and polygenic determinants of sarcoma risk: an international genetic study." Lancet Oncology 2016; 17(9): 1261-1271.
Sawyer S, Mitchell G, McKinley J, Chenevix-Trench G, Beesley J, Chen XQ, Bowtell D, Trainer AH, Harris M, Lindeman GJ and James PA (2012). A role for common genomic variants in the assessment of familial breast cancer. J Clin Oncol; 30(35): 4330-4336.
Antoniou, AC, Casadei S, Heikkinen T, Barrowdale D, Pylkas K, Roberts J, Lee A, Subramanian D, De Leeneer K, Fostira F, Tomiak E, Neuhausen SL, Teo ZL, Khan S, Aittomaki K, Moilanen JS, Turnbull C, Seal S, Mannermaa A, Kallioniemi A, Lindeman GJ, Buys SS, Andrulis IL, Radice P, Tondini C, Manoukian S, Toland AE, Miron P, Weitzel JN, Domchek SM, Poppe B, Claes KB, Yannoukakos D, Concannon P, Bernstein JL, James PA, Easton DF, Goldgar DE, Hopper JL, Rahman N, Peterlongo P, Nevanlinna H, King MC, Couch FJ, Southey MC, Winqvist R, Foulkes WD and Tischkowitz M. Breast-cancer risk in families with mutations in PALB2. 2014 N Engl J Med; 371(6): 497-506.