The program is interested in understanding the key role played by non-malignant cells within the tumour microenvironment, which includes stromal cells, blood vascular endothelial cells, lymphatic endothelial cells and immune cells.
The interaction of these cells types with tumour cells can either support or inhibit tumour progression. The spread of cancer to lymph nodes and distant organs is a critical aspect of cancer progression and is facilitated by lymphatic and blood vessels. The cells that line these vessels (endothelial cells) are the control points for changes to vessel structure and activity.
The program provides broad opportunities for training of postgraduate students, postdoctoral fellows, pathology fellows and clinically trained researchers in areas of basic scientific research, translational research and molecular pathology.
Key collaborative papers
Le CP, Nowell CJ, Kim-Fuchs C, Botteri E, Hiller JG, Ismail H, Pimentel MA, Chai MG, Karnezis T, Rotmensz N, Renne G, Gandini S, Pouton CW, Ferrari D, Möller A, Stacker SA, Sloan EK (2016). Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination. Nat Commun. 7:10634.
Sato T, Paquet-Fifield S, Harris NC, Roufail S, Turner DJ, Yuan Y, Zhang YF, Fox SB, Hibbs ML, Wilkinson-Berka JL, Williams RA, Stacker SA, Sly PD, Achen MG (2016). VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury. J Pathol. 239(2):152-61.
Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG (2014). Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 14(3):159-72.
Karnezis T, Shayan R, Caesar C, Roufail S, Harris NC, Ardipradja K, Zhang YF, Williams SP, Farnsworth RH, Chai MG, Rupasinghe TW, Tull DL, Baldwin ME, Sloan EK, Fox SB, Achen MG, Stacker SA (2012). VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium. Cancer Cell. 21(2):181-95.