VCFG publications and resources

SELECTED KEY PUBLICATIONS

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma. Smith LK, Parmenter T, Kleinschmidt M, Kusnadi EP, Kang J, Martin CA, Lau P, Patel R, Lorent J, Papadopoli D, Trigos A, Ward T, Rao AD, Lelliott EJ, Sheppard KE, Goode D, Hicks RJ, Tiganis T, Simpson KJ, Larsson O, Blythe B, Cullinane C, Wickramasinghe VO, Pearson RB, McArthur GA.Nat Commun. 2022 Mar 1;13(1):1100. doi: 10.1038/s41467-022-28705-x.

miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma. Holliday H, Yang J, Dodson E, Nikolic I, Kamili A, Wheatley M, Deng N, Alexandrou S, Davis TP, Kavallaris M, Caldon CE, McCarroll J, De Preter K, Mestdagh P, Marshall GM, Simpson KJ, Fletcher J, Swarbrick A.Mol Ther. 2022 Mar 2;30(3):1119-1134. doi: 10.1016/j.ymthe.2022.01.004. Epub 2022 Jan 5.

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids. Choo N, Ramm S, Luu J, Winter JM, Selth LA, Dwyer AR, Frydenberg M, Grummet J, Sandhu S, Hickey TE, Tilley WD, Taylor RA, Risbridger GP, Lawrence MG, Simpson KJ.SLAS Discov. 2021 Oct;26(9):1107-1124. doi: 10.1177/24725552211020668. Epub 2021 Jun 11.

Phenotypic Consequences of SLC25A40-ABCB1 Fusions beyond Drug Resistance in High-Grade Serous Ovarian Cancer. Pishas KI, Cowley KJ, Pandey A, Hoang T, Beach JA, Luu J, Vary R, Smith LK, Shembrey CE, Rashoo N, White MO, Simpson KJ, Bild A, Griffiths JI, Cheasley D, Campbell I, Bowtell DDL, Christie EL.Cancers (Basel). 2021 Nov 11;13(22):5644. doi: 10.3390/cancers13225644.


The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW.Cell. 2021 Jun 10;184(12):3143-3162.e32. doi: 10.1016/j.cell.2021.04.022. Epub 2021 May 17.

CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition. Lawrence MG, Porter LH, Choo N, Pook D, Grummet JP, Pezaro CJ, Sandhu S, Ramm S, Luu J, Bakshi A, Goode DL, Sanij E, Pearson RB, Hannan RD, Simpson KJ, Taylor RA, Risbridger GP, Furic L.Mol Cancer Ther. 2021 Nov;20(11):2140-2150. doi: 10.1158/1535-7163.MCT-20-0932. Epub 2021 Aug 19.PMID: 34413130

High-content siRNA 3D co-cultures to identify myoepithelial cell-derived breast cancer suppressor proteins. Duivenvoorden HM, Brockwell NK, Nowell CJ, Simpson KJ, Parker BS. Sci Data. 2021 May 28;8(1):147. doi: 10.1038/s41597-021-00924-9.

Genome-wide genetic screen identifies host ubiquitination as important for Legionella pneumophila Dot/Icm effector translocation. Ong SY, Schuelein R, Wibawa RR, Thomas DW, Handoko Y, Freytag S, Bahlo M, Simpson KJ, Hartland EL.Cell Microbiol. 2021 Oct;23(10):e13368. doi: 10.1111/cmi.13368. Epub 2021 Jun 8.

Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen. King LE, Zhang HH, Gould CM, Thomas DW, Whitehead LW, Simpson KJ, Burgess AW, Faux MC.PLoS One. 2020 Oct 15;15(10):e0240746. doi: 10.1371/journal.pone.0240746. eCollection 2020.

Genome-wide RNAi screen for genes regulating glycolytic response to vemurafenib in BRAFV600 melanoma cells. Smith LK, Parmenter T, Gould CM, Madhamshettiwar PB, Sheppard KE, Simpson KJ, McArthur GA.Sci Data. 2020 Oct 12;7(1):339. doi: 10.1038/s41597-020-00683-z.


Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells. Bortnik V, Wu M, Julcher B, Salinas A, Nikolic ISimpson KJ, McMillan NA, Idris A.J Microbiol Immunol Infect. 2021 Aug;54(4):733-739. doi: 10.1016/j.jmii.2020.07.010. Epub 2020 Jul 30.

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma. Gotovac JR, Liu DS, Yates MJ, Milne JV, Macpherson AASimpson KJ, Eslick GD, Mitchell C, Duong CP, Phillips WA, Clemons NJ.J Pathol. 2020 Nov;252(3):317-329. doi: 10.1002/path.5528. Epub 2020 Sep 15.

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex. Sharp MF, Murphy VJ, Twest SV, Tan W, Luu JSimpson KJ, Deans AJ, Crismani W.Sci Rep. 2020 May 14;10(1):7959. doi: 10.1038/s41598-020-64868-7.