Target discovery & validation

Researchers at Peter Mac strive to link recent advances in genetics, genomics, cell and chemical biology, pharmacology and medicine for improved drug target discovery through the efforts of our research laboratories and core facilities. Approaches include in vitro and in vivo screening, small molecule high-throughput screening, pre-clinical imaging and genetically engineered mouse models, among many others.


  • Next Generation Sequencing
  • High density SNP arrays
  • Expression Profiling
  • Proteomics
  • Bioinformatics and Computational Biology

Functional Genomics

  • shRNA lentiviral libraries
  • siRNA high-throughput screening
  • High content imaging

Tissue Banks

  • biospecimens with cancer tissue from 11,000 patients
  • Victorian Cancer Biobank collaborations

Genetically Engineered Mouse Models of Cancer

  • Solid tumours
  • Haematological

Primary Human Cancer Xenografts

  • Solid tumours
  • Haematological

Drug Evaluation

  • in-vitro testing
  • in-vivo testing
  • small molecules
  • biologics

Drug Discovery

  • CRC for Cancer Therapeutics

Pre-clinical Imaging

  • PET
  • Ultrasound
  • Tracer development

For further information on any of these resources, please contact the Technology Transfer Office who can link you with the relevant program.