Breast stream: Surgical research

The breast service participates in clinical breast cancer research and has strong links with basic science colleagues at Peter Mac, Royal Melbourne Hospital, Walter and Eliza Hall Institute and the University of Melbourne.

Research focus

  • Natural history of breast cancer and DCIS
  • Population-based mammographic screening
  • Tailored management of early breast cancer
  • Locoregional therapy clinical trials
  • Molecular assays in early breast cancer
  • Risk management for high-risk patients
  • MRI and other advanced imaging for early breast cancer

Research projects

  • Breast Cancer Database
  • Exploring women’s experience of theatre care whilst undergoing major breast surgery: a qualitative study
  • Assessment of outcomes in breast reconstruction after mastectomy
  • The impact of MRI on the surgical management of the breast
  • A Phase II randomized study of perioperative beta-blocker vs placebo on gene expression in newly diagnosed breast cancer
  • Does neoadjuvant therapy result in a change in PD-L1 receptor expression in breast cancer?
  • A randomised trial of axillary node dissection in women with clinical T1 or T2 N0 M0 breast cancer who have a positive sentinel node
  • Granulomatous Mastitis – the tip of the iceberg

Major ongoing clinical trials

  • Neo-Adjuvant chemotherapy for locally advanced cancer
  • POSNOC – Positive Sentinel Node, adjuvant therapy alone or axillary clearance
  • PROSPECT – Post operative radiotherapy omission in selected patients in early breast cancer therapy

Current PhD and other project themes

  • breast cancer genomics;
  • breast cancer biology;
  • breast density and breast cancer;
  • the natural history, genetics and prediction of outcomes for DCIS;
  • selective use of adjuvant radiotherapy in early breast cancer;
  • role of axillary dissection with low volume disease in sentinel nodes;
  • medical prevention of breast cancer in high-risk populations;
  • utility of molecular assays in early breast cancer;
  • studies of population-based mammographic screening.


Prof Bruce Mann

Email: [email protected]

Prof Michael Henderson

Email: [email protected]

Further info: 

Multidisciplinary Team Surgeon Lead

Prof Bruce Mann

Tumour Stream Surgeons

Dr Laura Chin-Lenn

A/Prof John Collins

Mr David Gyorki

Prof Michael Henderson

Dr Craig Murphy

Dr Sophie Nightingale

Dr Cathie Poliness

Dr Anita Skandarajah

Mr David Speakman

Mr Robert Tasevski

Ms Chantel Thornton