Breast stream: Surgical research

• Natural history of breast cancer and DCIS
• Population-based mammographic screening
• Tailored management of early breast cancer
• Locoregional therapy clinical trials
• Molecular assays in early breast cancer
• Risk management for high-risk patients
• MRI and other advanced imaging for early breast cancer

Research projects

• Breast Cancer Database
• Exploring women’s experience of theatre care whilst undergoing major breast surgery: a qualitative study
• Assessment of outcomes in breast reconstruction after mastectomy
• The impact of MRI on the surgical management of the breast
• A Phase II randomized study of perioperative beta-blocker vs placebo on gene expression in newly diagnosed breast cancer
• Does neoadjuvant therapy result in a change in PD-L1 receptor expression in breast cancer?
• A randomised trial of axillary node dissection in women with clinical T1 or T2 N0 M0 breast cancer who have a positive sentinel node
• Granulomatous Mastitis – the tip of the iceberg

Major ongoing clinical trials

• Neo-Adjuvant chemotherapy for locally advanced cancer
• POSNOC – Positive Sentinel Node, adjuvant therapy alone or axillary clearance
• PROSPECT – Post operative radiotherapy omission in selected patients in early breast cancer therapy

Current PhD and other project themes

• breast cancer genomics;
• breast cancer biology;
• breast density and breast cancer;
• the natural history, genetics and prediction of outcomes for DCIS;
• selective use of adjuvant radiotherapy in early breast cancer;
• role of axillary dissection with low volume disease in sentinel nodes;
• medical prevention of breast cancer in high-risk populations;
• utility of molecular assays in early breast cancer;
• studies of population-based mammographic screening.