Surgical management of melanoma at all disease stages

Active research protocols are reviewed regularly and our aim is to maximise the number of patients on current studies. In addition to major studies both investigator lead and other multicentre studies, a large number of studies undertaken by junior trainees utilising Peter Mac’s extensive patient numbers and databases are undertaken.

Research projects

Major studies

  • Multicenter Selective Lymphadenectomy Trial (MSLT-II): A Phase III Multicenter Randomised Trial of Sentinel Lymphadenectomy and complete Lymph Node Dissection versus Sentinel Lymphadenectomy Alone in Cutaneous Melanoma Patients with Molecular or Histopathological Evidence of Metastases in the Sentinel Node
  • A randomised clinical trial of surgery versus surgery plus adjuvant radiotherapy for regional control in patients with completely resected lymph node recurrence ANZMTG - TROG
  • Melbourne Melanoma Project - prospective demographic and genomic database
  • Randomised Trial of Inguinal v Inguinal plus Pelvic lymphadenectomy for patients with inguinal recurrence of melanoma
  • Use of Glubran2 to reduce seroma formation following inguinal lymphadenectomy - a randomised phase II trial
  • A prospective cohort study of patients with stage 3 and 4 melanoma at Peter MacCallum Cancer Centre
  • A Phase III, multi-centre, multi-national randomised control trial investigating 1cm v 2cm wide excision margins for primary cutaneous melanoma

Clinical research

  • Surgical Margins and prognosis in advanced melanoma of the head and neck; a retrospective study
  • Growth dynamics of malignant melanoma
  • Review of Rose-Bengal in cutaneous melanoma metastasis- The Peter Mac Experience
  • Resected macroscopic nodal metastatic malignant melanoma
  • Characteristics and prognosis of cutaneous SCC in patients with CLL
  • Anal Melanoma; a review of the Peter MacCallum Cancer Case Series
  • a multi-center, retrospective review of treatment patterns and outcomes for patients with locally advanced or metastatic basal cell carcinoma in australia
  • The staging of patients presenting with newly diagnosed stage III melanoma
  • Management and outcome of patients with high risk (>4mm) T4 melanomas
  • The Outcome of Patients with Popliteal and Epitochlear Sentinel Nodes
  • Studying the effect of mutation type on the immune phenotype of melanoma – a pilot study
  • Prognostic factors for early local recurrence of cutaneous melanoma
  • A prospective cohort study of patients with stage 3 and 4 melanoma at Peter MacCallum Cancer Centre
  • Identifying the prospective significance of immune infiltrate in primary melanoma


Prof Michael A Henderson

Email: [email protected]

Further info: 

Multidisciplinary Team Surgeon Lead

Prof Michael A Henderson

Tumour Stream Surgeons

Mr David Speakman

Mr John Spillane

Mr David Gyorki

Mr Simon Donahoe

Mr Miklos Pohl

Dr Angela Webb

A/Prof Chris McCormack

Dr Michelle Goh