Molecular Haematology

Myeloproliferative Neoplasm (MPN) Gene Panel – 22 genes 

JAK2, CALR, MPL, SF3B1, KIT, CSF3R, ETNK1, SH2B3, ASXL1, CBL, EZH2, IDH1, IDH2, KRAS, NRAS, RUNX1, SETBP1, SRSF2, TET2, TP53, U2AF1, ZRSR2.  

$475 (non-MBS eligible) 

$357 (MBS item 73398) 

$612.10 (MBS item 73399) 

Preferred samples: 4 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA) 

TAT: 28 days 

Methodology: Next Generation Sequencing (NGS)  

Haematological Malignancy (ALLHAEM) Gene Panel – 57 genes 

ABL1, ARAF, ASXL1, BCL2, BIRC3, BRAF, BTK, CALR, CARD11, CBL, CD274, CD79B, CEBPA, CSF3R, CXCR4, DDX41*, DNMT3A, ETNK1, EZH2, FLT3**, FYN, GATA1, GATA2, ID3, IDH1, IDH2, IRF8, JAK2, JAK3, KIT, KRAS, MAP2K1, MPL, MYD88, NOTCH1, NPM1, NRAS, PDCD1LG2, PIGA, PFH6, PLCG1, PLCG2, RHOA, RUNX1, SETBP1, SF3B1, SH2B3, SRSF2, STAT3, STAT5B, STAT6, TCF3, TET2, TP53, U2AF1, XPO1, ZRSR2. 

*Excluded on request.  

**FLT3-ITD included when request   

$850 (non-MBS eligible) 

$653.65 (MBS item 73314) 

Preferred samples:  

4 ml peripheral blood (EDTA);  

1-2 ml bone marrow (EDTA); 

Tissue – fresh or FFPE block/slides (10 x 5 micron sections on positively charged slides) 

TAT: 28 days 

Methodology: Next Generation Sequencing (NGS)  

TP53 Gene Variant Analysis  

TP53 

$475 (not MBS covered) 

Preferred samples:  

4 ml peripheral blood (EDTA) 

1-2 ml bone marrow (EDTA) 

Tissue – fresh or FFPE block/slides (10 x 5 micron sections on positively charged slides) 

TAT: 28 days 

Methodology: Next Generation Sequencing (NGS)  

FLT3-ITD & TKD 

$196.35 (non-MBS eligible) 

Fully covered (MBS item 73314) 

Preferred samples:  

4 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA) 

TAT: 7 days 

Methodology: Fragment analysis by capillary electrophoresis  

NPM1 (non-quantitative) 

$196.35 (non-MBS eligible) 

Fully covered (MBS item 73314) 

Preferred samples:  

4 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA) 

TAT: 7 days 

Methodology: Fragment analysis by capillary electrophoresis  

BCR::ABL1  

$196.35 (non-MBS eligible) 

Fully covered (MBS item 73314) 

Preferred samples:  

20 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA).  

Sample must be received within 72 hours of collection. 

TAT: 7 days 

Methodology: reverse transcription quantitative PCR (RT-qPCR) 

PML::RARA 

$196.35 (non-MBS eligible) 

Fully covered (MBS item 73314) 

Preferred samples:  

20 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA).  

Sample must be received within 72 hours of collection  

TAT: 14 days 

Methodology: reverse transcription quantitative PCR (RT-qPCR)  

RUNX1::RUNX1T1 

$196.35 (non-MBS eligible) 

Fully covered (MBS item 73314) 

Preferred samples:  

20 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA).  

Sample must be received within 72 hours of collection.  

TAT: 14 days 

Methodology: reverse transcription quantitative PCR (RT-qPCR)  

CBFB::MYH11 

$196.35 (non-MBS eligible) 

Fully covered (MBS item 73314) 

Preferred samples:  

20 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA).  

Sample must be received within 72 hours of collection. 

TAT: 14 days 

Methodology: reverse transcription quantitative PCR (RT-qPCR)  

NPM1 MRD 

Type A, B or D 

$196.35 (non-MBS eligible) 

Fully covered (MBS item 73314) 

Preferred samples:  

20 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA).  

Sample must be received within 72 hours of collection.  

TAT: 14 days 

Methodology: reverse transcription quantitative PCR (RT-qPCR)  

Chimerism Analysis 

$129 (not MBS covered) 

Preferred samples:  

4 ml (pre-transplant)/ 18 ml (post-transplant) peripheral blood (EDTA) OR  

1-2 ml bone marrow (EDTA).  

Post-transplant samples must be received within 72 hours of collection.  

TAT: 14 days 

Methodology: Short tandem repeat (STR) fragment analysis by capillary electrophoresis  

IGHV Somatic Hypermutation Analysis 

$400 (not MBS covered) 

Fully subsidised by Wilson Centre for Blood Cancer Genomics (if eligible – refer to request slip for eligibility criteria) 

Preferred samples: 

4 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA) 

TAT: 28 days  

HAVCR2 Gene Variant Analysis 

$250 (not MBS covered) 

Preferred samples:  

4 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA) 

TAT: 28 days 

Methodology: Sanger sequencing 

UBA1 Gene Variant Analysis 

$250 (not MBS covered) 

Preferred samples:  

4 ml peripheral blood (EDTA) OR 1-2 ml bone marrow (EDTA) 

TAT: 28 days 

Methodology: Sanger sequencing 

DNA Storage + Extraction 

$37.50