Congratulations to Professor Joe Trapani and Professor David Bowtell who have been elected Fellows of the Australian Academy of Science for 2018.

David and Joe, who are both past Executive Directors of Cancer Research, are the second and third Peter Mac scientists to become Fellows, joining Joseph Sambrook who was elected in 2000. 

The Australian Academy of Science is a Fellowship of the nation’s most distinguished scientists, elected by their peers for outstanding contribution to science and scientific research.

Watch Joe and David speaking about being elected as Fellows and the work that led to their nomination. 

Professor Joe Trapani

Joe Trapani is an immunologist whose research focuses on how cells of the immune system kill harmful cells - those infected with a virus or undergoing cancerous transformation. He discovered several diverse toxins that mediate cell death, and determined how they function, individually and in synergy. His studies also address structure/function relationships for the pore-forming protein perforin and the signalling pathways activated by the ‘granzyme’ proteases to induce target cell apoptosis. Joe also elucidated how defects in cell death pathways impinge on human health and disease, and how immune ‘killer cells’ can be harnessed as therapies for cancer, viral and auto-immune diseases.

For more information see Trapani Laboratory

Professor David Bowtell

David Bowtell is an internationally recognised expert in ovarian cancer research and a pioneer in genomics and personalised medicine. He has made seminal discoveries relating to ovarian cancer classification, primary and acquired chemotherapy resistance, and factors influencing patient survival. His research has identified molecular subtypes of high-grade serous ovarian cancer, enabling subtype-specific clinical trials, and highlighted novel mechanisms of acquired resistance. His work on BRCA1/2 germline mutation-prevalence resulted in the comprehensive revision of genetic testing guidelines for ovarian cancer in Australia and internationally. In his early career, he also made major contributions to characterisation of RAS signal transduction.

For more information see the Bowtell Laboratory