Molecular Haematology

The Molecular Haematology Laboratory at Peter MacCallum Cancer Centre provides the basis for genomically personalised care to patients with haematological malignancies.

The Molecular Haematology Laboratory at Peter MacCallum Cancer Centre utilises a range of conventional and novel (next generation sequencing) technologies in order to improve outcomes of patients with haematological malignancies. Acknowledging the rapid advancements and explosion of literature in molecular haematology this medically-led and clinically focussed service aims to provide more than just simple testing, but rather to provide a high-level of clinical and scientific guidance and support around test choice and test interpretation. The Molecular Haematology Laboratory offers :

  • A dedicated clinical and laboratory molecular haematologist Dr. Piers Blombery and multiple expert senior post-doctoral molecular haematology scientific staff
  • A Molecular Multidisciplinary team (MDT) meeting  attended by clinical and laboratory haematologists, senior molecular haematology scientific staff and a medical geneticist which is run fortnightly. The Molecular Haematology MDT focusses on NGS-based assay interpretation and assessment of potential germline variants in somatic testing as well as being a forum for general molecular education of medical and scientific staff. Teleconference facilities are available for external referrers. 
  • A clinical molecular consultative service in order to guide the most appropriate choice of testing, patient education and consent and post-test analysis
  • A NATA-accredited NGS service

Tests available

Next generation sequencing

Myeloproliferative Neoplasm Diagnostic Amplicon Panel - JAK2, MPL, CALR, KIT, SF3B1, CSF3R, ASXL1

Myeloid Amplicon Panel - ASXL1, BRAF, CALR, CBL, CSF3R, DNMT3A, EZH2, FLT3, GATA2, IDH1, IDH2, JAK2, JAK3, KIT, KRAS, MPL, NPM1, NRAS, RUNX1, SETBP1, SF3B1, SRSF2, TET2, TP53, U2AF1, WT1

Lymphoid Amplicon Panel - ARAF, BIRC3, BRAF, BTK, CARD11, CD79B, CXCR4, DNMT3A, EZH2, FOXO1, FYN, ID3, IDH1, IDH2, JAK3, KRAS, MAP2K1, MYD88, NOTCH1, NRAS, PHF6, PLCG1, PLCG2, RHOA, RUNX1, SF3B1, STAT3, STAT5B, STAT6, TCF3, TP53, XPO1

NGS MRD testing – NPM1*
           *other gene targets possible, please contact laboratory for further information

Conventional testing

Quantitative PCR for PML-RARA, inv(16), RUNX1-RUNX1T1
IGH/TCR clonality testing
IGVH mutation status testing for CLL  
NPM1/FLT3-ITD testing
JAK2 testing
KIT D816V testing
CEBPA testing

and more...

Please contact laboratory for further information.

CONTACT INFORMATION

Phone: +61 3 8559 8402
Fax : +61 3 8559 5419