Molecular Pathology

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Molecular Pathology - Research at Peter Mac

The Molecular Pathology Research and Development laboratory aims to perform basic and translational research with the goal of achieving personalised cancer medicine.

Research Focus

Translational and clinical research into breast, lung, colorectal, urological and haematological cancers. Identification of predictive markers enabling appropriate stratification of patients for individualised treatment. Development of clinical diagnostics. Adoption of novel molecular platforms and methodologies for genetic and epigenetic analysis.

Research Overview

The genomic era has brought a paradigm shift to laboratory medicine such that many tumours now require molecular characterisation for accurate prognostic assessment and appropriate treatment stratification. The Molecular Pathology Research and Development laboratory prides itself on being at the cutting edge of this exciting new era, introducing novel testing technologies and transferring such tests into the clinical environment. We oversee the platform selection and the design, introduction and accreditation of such new tests. Our laboratory also performs basic and translational research in three principle areas: the effect of angiogenesis and microenvironmental factors (particularly hypoxia) on tumour behaviour; the role of epigenetic change in the predisposition to cancer; and identification and use of genetic and epigenetic markers capable of predicting responses to conventional and novel therapies.