Gene Regulation Publications & Patents

Gene Regulation Publications & Patents - Research at Peter Mac

Recent Publications

Whitecross, K.F., Alsop, A.E., Cluse, L.A., Wiegmans, A., Banks, K.M., Coomans, C., Peart, M.J., Newbold, A., Lindemann, R.K., Johnstone, R.W. Defining the target specificity of ABT-737 and synergistic anti-tumor activities in combination with histone deacetylase inhibitors. 2009 Blood 113(9):1982-91 [<,10.9].
Bolitho, P, Street, S.E.A., Westwood, J.A., Edelmann, W., MacGregor, D., Waring, P., Murray, W.K., Godfrey, D.I., Trapani, J.A., Johnstone, R.W., Smyth, M.J. Perforin-mediated suppression of B cell lymphoma. 2009 Proc Natl Acad Sci U S A. 106(8):2723-8.. [<,9.6]
Bolden, J.E., Johnstone, R.W., Frew, A.J. Enhancing the apoptotic and therapeutic effects of HDAC inhibitors. 2009 Cancer Letters 280(2):125-33. [<, 3.4].
Algar EM, Muscat A, Dagar V, Rickert C, Chow CW, Biegel JA, Ekert PG, Saffery R, Craig J, Johnstone RW, Ashley DM. Imprinted CDKN1C Is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. 2009 PLoS ONE. 2009;4(2):e4482
Ellis L, Bots M, Lindemann RK, Bolden JE, Newbold A, Cluse LA, Scott CL, Strasser A, Atadja P, Lowe SW, Johnstone R.W. The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. 2009 Blood 14(2):380-93.
Bots M. and Johnstone RW. Rational combinations using HDAC inhibitors. 2009 Clin. Cancer Res. 2009 15(12):3970-7
Ellis L., Atadja PW and Johnstone RW. Epigenetics in Cancer: Targeting Chromatin Modifications. 2009 Molecular Cancer Therapeutics 2009 8(6):1409-20.
Prince HM, Bishton MJ, Johnstone RW. Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors. Future Oncol. 2009 Jun;5(5):601-12.

Patents

Patent No. - 60/137933
Year taken out – 1999
Inventors – Dr Ricky W. Johnstone, Dr Mark M. Smyth
Assignee – The Austin Research Institute
Title – Cells for identifying potential therapeutics.

Patent No. – PQ5528
Year taken out – 2000
Inventors – Dr Ricky W. Johnstone, Dr Joseph A. Trapani
Assignee – The Austin Research Institute
Title – Promoters and regulators thereof.

Patent No. PR7167
Year taken out – 2001
Inventors – Dr Ricky W. Johnstone, Dr Mark M. Smyth
Assignee – The Peter MacCallum Cancer Institute
Title – Methods of inducing cell death and methods of treatment.

Patent No. PCT/AU01/01635
Year taken out – 2001
Inventors – Dr Andreas Suhrbier, Mr Grant Darnell, Dr Ricky W. Johnstone
Assignee – Queensland Institute of Medical Research
Title – Rb-binding protein.

Patent No. 61/108,319
Year taken out – 2008
Inventors –Dr Mitchell Keegan, Dr Ricky W. Johnstone, Ms Leonie Cluse, Ms Andrea Newbold
Assignee – Gloucester Pharmaceuticals
Title – Cancer Therapy